Peter Polgar: Eicosanoids and Radiation
Description
Prostaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging area of cancer research. In 1968, R.H. Williams first reported that elevated prostaglandin levels are present in human medullary car- cinoma. Since that time, the concept that arachidonic acid metabolites may be in- volved in cancer has expanded to include every aspect of the disease from cell transformation through metastasis. Prostaglandins and leukotrienes are generic terms used to describe a family of bioactive lipids produced from unsaturated fatty acids (principally from arachidonic acid) via the cyclooxygenase and lipoxygenase pathways, respec- tively. Cyclooxygenase products consist of diverse products such as prosta- glandin Ez (PGEz), prostacyclin (PGIz) and thromboxane Az (TXAz), whereas lipoxygenase products consist of hydroperoxy fatty acids and mono-, di- and tri-hydroxy acids including leukotrienes. The precursor fatty acids for the cyclooxygenase and lipoxygenase pathways are present in cellular phospholipids. This finding established an important control point in their biosynthesis-the release of substrate. This occurs in response to numerous stimuli that act at the cell surface. Dr. Bengt Samuelsson's extensive study of the metabolism of pros- taglandins indicated that they are rapidly inactivated on a single pass through pulmonary circulation. Thus, they cannot act as circulating hormones and appear to be made on demand in or in the vicinity of target tissues leading to the concept that prostaglandins are local hormones or autocoids.
This is a non-fiction thriller to match Mark Bowden's Killing Pablo and Roberto Saviano's Gomorrah. It also tells a wider story: the brutal war between the cartels, the endemic state corruption and the US complicity in a conflict that is killing more people than Iraq. Nonfiction pro Gail Gibbons responds to the need for books on good nutrition with this accessible exploration of vegetables. Glossy red peppers; lush, leafy greens; plump, orange pumpkins; and delectable little peas: vegetables come in many shapes, colours, and forms. Using her signature combination of a clear and informative Eicosanoids and Radiation download PDF text, with plenty of illustrations, diagrams, and cross sections, this book provides a wealth of information about produce. It covers: * flow and sediment regimes: flow generation; flow regimes; sediment sources, transfer and yield * channel processes: flow characteristics; processes of erosion and sediment transport; interactions between flow and the channel boundary; deposition * channel form and behaviour: controls on channel form; channel adjustments; floodplain development; form and behaviour of alluvial and bedrock channels * response to change: how channels have responded to past environmental change; impacts of human activity; reconstructing past changes * river management: the fluvial hydrosystem; environmental degradation; environmentally sensitive engineering techniques; river restoration; the role of the fluvial geomorphologist. Fundamentals of Fluvial Geomorphology is an indispensable text for undergraduate students. It provides straightforward explanations for important concepts and mathematical formulae, backed up with conceptual diagrams and appropriate examples from around the world to show what they actually mean and why they are important. A colour plate section also shows spectacular examples of fluvial diversity.
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Author: Peter Polgar
Number of Pages: 196 pages
Published Date: 22 Jan 2012
Publisher: Springer-Verlag New York Inc.
Publication Country: New York, NY, United States
Language: English
ISBN: 9781461289708
Download Link: Click Here
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